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Alterations of Epigenetic Regulators in Pancreatic Cancer

Abstract

James Rodrigue

Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of less than 10%. Despite advances in the treatment of other cancers, pancreatic cancer remains a difficult disease to treat due to its aggressive nature and late diagnosis. In recent years, there has been increasing interest in the role of epigenetics in the development and progression of pancreatic cancer. Epigenetics refers to modifications of DNA and histones that regulate gene expression without altering the underlying genetic code. Alterations in epigenetic regulators can lead to aberrant gene expression, resulting in the development and progression of cancer. In pancreatic cancer, several epigenetic regulators have been found to be deregulated, including DNA methylation, histone modifications and non-coding RNAs.