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An Osteogenic Effect of Arecoline in an Osteoporosis Model: A Mechanistic Analysis Heme Oxygenase-1 Expression-induced Iron Overload-induced Osteogenesis Inhibition

Abstract

Ferrder Verderd

Osteoporosis is a debilitating condition characterized by low bone mass and micro architectural deterioration of bone tissue, leading to increased bone fragility and susceptibility to fractures. Arecoline, an alkaloid found in the areca nut, has been investigated for its potential osteogenic effects in the context of osteoporosis. This article presents a mechanistic analysis of how Arecoline exerts an osteogenic effect in an osteoporosis model, focusing on its modulation of Heme Oxygenase-1 (HO-1) expression and its role in iron overload-induced osteogenesis inhibition.