ஜர்னல் ஆஃப் இம்யூனோபயாலஜி

Antibody-Based Targeted Therapy: A Novel Cancer Treatment

Abstract

Bahareh Sadri, Shirin Nouraein, Taravat Khodaei, Negin Vahedi and Javad Mohammadi*

Antibody based targeted therapy has considered more than other immunotherapeutic methods for cancer treatment due to extensive capacity of antibodies for targeting specific antigens. Antibodies and antibody fragments can target particular antigens that are expressed by cancer cells and lead them to apoptosis. However, conjugation of antibodies to cytotoxic agents such as drugs, radionuclides, and toxins improves the efficacy of antibody-based targeted therapy. The use of antibodies as carriers to deliver cytotoxic agents to the target cells has led to the emergence of immunoconjugates. The immunoconjugates not only are more effective than naked antibodies but also prevent the side effects of cytotoxic agents by delivering them only to the target cells. Targeted therapy has received more attention due to its fewer side effects on normal cells. This review provides a brief definition of various antibody therapies which are in development and in clinical use for different cancers treatment, as well as describes the mechanism of action of each method.