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Design, Synthesis and Anticonvulsant Activity of Some New Acetanilide Derivatives Incorporating Phthalazine- 1,4 (2H, 3H) Dione Scaffolds

Abstract

Ehab M. Mostafa, Ahmed M. Mansour, Yomna A Salem, Rezk R. Ayyad, Yasser Abdel-Aleim and Kazem Mahmoud

We prepared phthalazine -1,4 (2H, 3H) dione (1) from phthalic anhydride and hydrazine hydrate. The compound (1) reacted with alcoholic potassium hydroxide, we obtained on
compound (2) (the potassium salt of phthalazine -1,4 (2H, 3H) dione. Also we synthesized acetanilide derivatives (3) from aniline derivatives with chloroacetyl chloride. Then we reacted the compound (2) with the compounds (3) resulted compounds (4a-q) which tested some of them (some new compounds acetanilides) against phenobarbitone as standard reference drug as anticonvulsant agents, some of these new compounds revealed promising anticonvulsant activity.