Adriana Bocheva, Hristina Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume and Thierry Brigaud
The present study was undertaken to investigate the effects of novel CF3-(MIF-1) analogue on stress-induced analgesia after restraint and cold stress in rats. The analgesic effect of CF3-(MIF-1) has been evaluated by paw pressure (PP) and hot plate (HP), and compared to the native tripeptide MIF-1. Our hypothesis was that incorporation of the trifluoromethyl group (CF3) in the novel MIF-1 analogue molecule would increase its antagonizing effect in both tests and after both kinds of stress compared to the native tripeptide MIF-1.
The results obtained showed that both the non-fluorinated and the fluorinated peptides significantly decreased SIA in PP and HP tests during the whole investigated period and CF3-(MIF-1) had a stronger anti-opioid effect compared to MIF-1.
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