ஜர்னல் ஆஃப் ஆன்காலஜி மெடிசின் & பயிற்சி

High Dose Chemotherapy (HDCT) With Autologous Stem Cell Transplantation (ASCT) in Children with Solid and Central Nervous System (CNS) Tumors, a Single Centre Experience

Abstract

Baraka Bakrmum, Hala Omer, Ashraf Radwana, Ghufran Alhawaj, Jalilah ALsadiq, Qasim Alharbi, Saif El-Deen Al-Horanib, Saad ALdaama and Omer Chamdinea

Objectives: The Primary aim of this study is to assess the outcome of children with solid and CNS tumors who underwent HDCT and ASCT at King Fahad Specialist Hospital in Dammam, secondarily we aim to compare our local results with national and international outcomes, Identify the toxicities, and complications of this modality of treatment, and identify the outcome in term of overall survival and relapse and mortality rates.

Design: This is a retrospective cross-sectional study of all the pediatric patients below sixteen-year-old who diagnosed with solid tumor or central nervous system tumor and treated by high dose chemotherapy and autologous stem cell transplantation in king Fahd specialist hospital in Dammam, pediatric hematology/ oncology department between 1^st November 2011 and 29^th February 2020, our study included 33 cases.

Setting: It is a single center study at King Fahad Specialist Hospital in Dammam which is 400 beds tertiary referral hospital with 27 beds pediatric oncology Ward, 4 beds bone marrow transplant and 18 bed pediatric oncology day care services.

Methods and Results: After obtaining the IRB approval, all data and information of patients were retrieved from patients’ hard files and electronic medical records. Data analysis were done by using Statistical Package for the Social Sciences (SPSS) program version and stored in the Redcap system for confidentiality.

Results: Within our study period we diagnosed 33 cases who diagnosed with solid tumor or central nervous system malignancies and treated by high dose chemotherapy and autologous stem cell transplantation in king Fahd specialist hospital in Dammam, the overall survival was 66% with both the relapse rate and mortality rate were 33%.

Conclusion: In summary, despite being a single-center experience and relatively small sample size, yet we believe that our study showed that the approach of using HDCT followed by APBSCT for managing children with advanced malignant solid tumors is safe and effective with the best results obtained in those with complete remission status before that approach. A prospective study will be more suitable to evaluate whether HDCT with auto�??PBSCT will significantly impact the outcomes in the treatment of children with advanced malignant solid tumors. a serious international collaboration is crucial to design randomized trials aiming to address these expensive and high morbidity procedures in treating childhood advanced solid malignant tumors.