ஜர்னல் ஆஃப் ஃபார்முலேஷன் சயின்ஸ் & உயிர் கிடைக்கும் தன்மை

Impact of Polymorphism and Particle Size on the Bioavailability of Active Pharmaceutical Ingredients

Abstract

Carlos Lorena

Bioavailability is a critical factor in the efficacy of Active Pharmaceutical Ingredients (APIs). Two key physical properties influencing bioavailability are polymorphism and particle size. Polymorphism refers to the ability of a compound to exist in more than one crystalline form, while particle size impacts the dissolution rate and, consequently, the bioavailability of the API. This article explores the mechanisms by which polymorphism and particle size affect bioavailability, supported by recent research and case studies.