குளோபல் ஜர்னல் ஆஃப் டெக்னாலஜி அண்ட் ஆப்டிமைசேஷன்

Pharmacologically Active Substances’ Beneficial Effect on Telomere Length: Pharmacotherapeuti Considerations on Telomere Biology

Abstract

Rossiello LaBella

Telomeres, the protective caps at the ends of chromosomes, play a crucial role in maintaining genomic stability and cellular health. They consist of repetitive nucleotide sequences and associated proteins that prevent chromosomal degradation and maintain genomic integrity during cellular division. Telomere length is a key determinant of cellular lifespan and has implications for aging, disease susceptibility and overall health. Over the past decades, research has increasingly focused on understanding factors that influence telomere length dynamics, including the potential effects of pharmacologically active substances. This essay explores the current understanding of how pharmacologically active substances may affect telomere length and discusses Pharmacotherapeuti considerations related to telomere biology. It synthesizes findings from both experimental studies and clinical trials to provide a comprehensive overview of the topic.