மருத்துவ வேதியியல்

Phytochemical and Biological Investigation of Aloe Grandidentata Salm- Dyck

Abstract

Taghreed A Ibrahim, Nabaweya M EL Fiki, Ibrahim A Shehata, Amany A Sleem and Mouchira M Shoukry

The crude alcoholic extract of the leaves of Aloe grandidentata Salm.-Deck showed significant antimicrobial activity (200 mg/ml), potent anti-inflammatory and chronic antihyperglycemic (100 mg/kg b.wt.) compared to standard positive drugs. Phytochemical studies of the potent extract revealed the isolation and characterization of seven compounds; two new compounds; 1,1',8,8'-tetrahydroxy -3 ' - acetyl -3-methyl -5,5 ' bianthracene -9, 9 ' ,10,10 ' -tetraone (2) and 1,6,8-trihydroxy–7–methoxy–3- methyl anthraquinone (3), five known compounds, β-sitosterol (1), emodin (4), chrysophanol (5), physicon (6) and β-sitosterol-3-O-β–D-glucoside ( 7 ). This is the first report of the isolation of emodin and β-sitosterol-3-O-β–D-glucoside from genus Aloe and physicon from family Liliaceae. All structures of the isolated compounds were determined using several spectroscopic techniques; UV, IR, MS, NMR ( 1 H NMR and 13 C NMR) and by comparison with literature data.