எய்ட்ஸ் & மருத்துவ ஆராய்ச்சி இதழ்

Predictors of Status of Hepatitis B Virus among Adults under Treatment: A Retrospective Longitudinal Study

Abstract

Awoke Seyoum Tegegne and Awoke Fetahi

Background: Hepatitis B is the most common liver infection in the world which is caused by the Hepatitis B Virus (HBV). The virus can attack and injure the liver. The infection of hepatitis B virus leads to chronic viral hepatitis infections in hundreds of millions of people in worldwide. The objective of current study was to identify factors that affect the progression rate of hepatitis B virus in patients’ liver who were treated at Felege-Hiwot teaching and specialized hospital, during treatment period.

Methods: The data for this study was obtained from hepatitis B patients chart registered for treatment during January 2013 to December 2016 at chronic hepatitis B patients’ clinic at Felege-Hiwot teaching and specialized hospital, Bahir Dar, Ethiopia. A retrospective study design was conducted in current investigation. The estimation of the model parameters was done by Restricted Maximum Likelihood (REML) procedures.

Results: From the linear mixed effect model, main effects like visiting time (p-value<0.001), sex (p-value=0.0332), age (p-value<0.001), vaccination history (p-value=0.0141), marital status (p-value=0.0032), alanine aminotransferase (p-value=0.0057), genotype, A (p-value=0.0154), genotype, B (p-value=0.0183), genotype, C (p-value=0.0143) and albumin (p-value=0.0329) significantly affected the variable of interest. Similarly, interaction effects of time with marital status (p-value=0.0042) played statistically significance role on the progression rate of hepatitis B virus in the liver of patients.

Conclusion: A certain groups which are at maximum risk and needs intervention have been identified. Highly concrete evidences have been increased from time to time for certain population with chronic HBV infection being at great risk for progression of liver disease. Hepatitis B virus infected patients at the study area should have information about factors that can affect the progression rate of HBV. Ministry of health or health staff should aware the community to take vaccination that helps to protect individuals from hepatitis B virus.