Grazia Rutigliano*
Thyronamine (T0AM) and 3-iodothyronamine (T1AM) are novel endogenous signaling molecules that appear to counteract the actions of traditional thyroid hormone (T3) despite sharing a lot of structural similarities with thyroid hormones. Decarboxylation and some or all deiodination would be required for their proposed biosynthesis from thyroid hormones. Iodine is depleted from substrates by deiodinases (Dio1, Dio2 and Dio3). We investigated whether deiodinases convert thyronamines because thyronamine biosynthesis relies on deiodinases' capacity to accept thyronamines as substrates. Preparations of isozyme-specific deiodinase were incubated with thyronamines. A brand-new approach made use of tandem mass spectrometry (LC-MS/MS) and liquid chromatography was used to analyze the deiodination products.
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