மருத்துவ வேதியியல்

Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives

Abstract

Bala Guraiah Mothukuri, Triloknadh Settypalli, Nagaraju Begari, Vijaya Kumari Dalavai and Venkata Rao Chunduri

With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3. All newly synthesized target compounds (4a-4n) were characterized by 1H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram positive: Bacillus subtilis, Gram negative: Escherichia coli) which confirmed that compounds 4a, 4b, 4d, 4g, 4h and 4n have potent activity against B. subtilis as compare with gentamicin at concentration 500 μg/mL. We hope that this study may helpful for further optimization in finding of lead antimicrobial from the origin of benzimidazole linked oxadiazole derivatives.