Ahmed M El-Malky, Ramachandra G Naik
Background: Disturbance in renal function was considered to be a common complication of Cyclosporine-A (CsA) treated patients of recent-onset type 1 diabetes mellitus, for purposes of remission. The aim of the present study was to scrutinize the potential association between this drug and its complications by conducting a meta-analysis of randomized control trials.
Methods: A consummate literature search of PubMed, EMBASE, and web of science was conducted until March 2019. A total of 9 randomized control trials were included in this meta-analysis.
Results: On meta-analysis of nine studies evaluating the risk of transient complications, analysis of the random effect of 12 months-low dose-cyclosporine on serum creatinine, revealed the absence of CsA induced nephrotoxicity. And no association between CsA and renal function in newly diagnosed type 1 diabetic patients Odds Ratio (OR), 1.06; 95% Confidence Interval (CI), 1.00-1.43; I2=73.1%). No noteworthy publication bias was noticed in the designated 9 studies.
Conclusion: 12 months low dose CsA was not associated with risk of deterioration of renal function according to the results revealed from the meta-analysis of RCTs which is considered as the summit of the research pyramid.
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