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Modern Synthesis of Triflamides and Triflimides

Abstract

Bennett Ramky

N-Trifluoromethanesulfonamides (CF3SO2NHR, TfNHR) have found extensive use in natural union over the past two decades as reagents, catalysts, additives, and substituents that alter reactivity and organic movement in a variety of substrates. Early surveys on the subject of triflamide and its subordinates were conducted, which supports the enormous interest in such constructs. Triflamides are among the most grounded NH- acids since they have significant areas of strength for a pulling out CF3SO2 bunch in their design (pKa (in H2O) for TfNH2 is 6.33, pKa (in H2O) for Tf2NH is 2.8). This characteristic determines how triflamides are used in natural blends, in the production of pharmaceutically and organically active chemicals, as well as in various industries.