ஜர்னல் ஆஃப் நெப்ராலஜி & தெரபியூட்டிக்ஸ்

Optimal Vitamin D levels in Children with Chronic Kidney Disease

Abstract

Ki Wuk Lee,Sang Taek Lee,Heeyeon Cho*

Background: Vitamin D is an essential component of skeletal development. Although hypovitaminosis D has been widely observed, little data for vitamin D status in pediatric patients with chronic kidney disease (CKD) has been reported. The aim of this study was to assess the prevalence of abnormal vitamin D status and analyze factors associated with inadequate 25(OH) vitamin D (25(OH)D) levels in children with CKD.

Methods: Serum 25(OH)D levels and other parameters associated with vitamin D status were evaluated by a cross-sectional study of pediatric patients with predialysis CKD stage 2-5 at Samsung Medical Center located in Seoul, Republic of Korea. Vitamin D deficiency and insufficiency were defined as a serum 25(OH)D level < 20 ng/mL and 20- 30 ng/mL, respectively.

Results: Of the 113 pediatric patients with CKD, vitamin D deficiency or insufficiency was found in 77.8% of the patients and 54.9% had a diagnosis of vitamin D deficiency with a serum 25(OH)D levels below 20 ng/mL. An increasing prevalence of vitamin D deficiency in advanced CKD was observed Age and PTH levels were negatively associated with 25(OH)D levels in pediatric CKD patients.

Conclusion: This study demonstrated that a prevalence of 25(OH)D insufficiency and deficiency are common in children with CKD. The age effect on abnormal vitamin D status was observed in pediatric patients with CKD, and future studies to adjust the guideline for vitamin D supplementation according to the age is needed.