குழந்தை நரம்பியல் மற்றும் மருத்துவ இதழ்

Role of Serum Procalcitonin as a marker of neonatal sepsis

Abstract

Dr. Pradeep Gupta

Despite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. Hospital Based prospective observational study.50 neonates (preterm &term) with clinically suspected sepsis were studied during 1 year from Jan 2016 to Dec 2016 in Chaitanaya Hospital Chandigarh. Conventional sepsis workup was done in all cases and the diagnosis of neonatal sepsis was proved based on the results of blood culture. The serum Procalcitonin was measured by quantitative Enzyme linked imunofluroscence assay and the results were compared to CRP levels between the neonates with or without proven sepsis. Of the total 220 babies admitted in NICU during that period 50 were eligible for study and analyzed. 24 % babies had Definite Sepsis, 60% had Probable Sepsis and 16% babies had  No Sepsis. Of the neonates with suspected sepsis 24 % had culture positive and 76% were culture negative. Mean PCT level was 13.27+- 33.2 ng/ml.