மூலக்கூறு மற்றும் மரபணு மருத்துவம்

Adipose-Derived Stem Cells (ASC) Communicate with Residual Breast Cancer Cells

Abstract

Reinkens T, Vogt PM and Bucan V

Purpose: Based on aesthetics and long-term stability, call-assisted autologous lipotransfer is a promising method for post-oncological breast reconstruction. Thereby, autologous fat grafts enriched with autologous adiposederived stem cells are transferred to the breast. However, as adipose-derived stem cells (ASC) have the ability to secrete exosomes and growth factors, they could communicate with residual breast cancer cells.

Methods: We performed a systematic review of the published literature to evaluate whether adipose-derived stem cells- based treatments for breast cancer are associated with tumor growth of rest breast cancer cells and therefore that it could exist an oncological risk. An electronic database search was performed.

Results: As described, all current studies can prove that the gene expression is influenced by the direct cell contact between adipose-derived stem cells and breast cancer cells.

Conclusion: These observations suggest that information is substituted via exosomes which can migrate intercellularly and transfer genetic material between both cell types.