மருந்தியல் மற்றும் இயற்கை தயாரிப்புகளின் இதழ்

Cytotoxic Effects of Lysimachia ramosa Wall. Ex Duby (Primulaceae) on Swiss Albino Mice

Abstract

Bishnupada Roy and Paulomi Dey

Lysimachia ramosa is a traditional medicinal plant, consumed by different tribes of northeast India to cure intestinal helminth infections. In order to measure the toxic effects of the plant on its consumer, if any, the present in vivo study was carried out on mice using sub-lethal doses of crude ethanol extract viz. 100 and 200 mg/kg body weight for 14 days. Surface topographical and ultrastructural observations on liver, kidney and intestine of treated mice revealed marked deformation and destruction accompanied by quantitative changes in liver and kidney markers like aspartate aminotransferase, alanine aminotransferase and creatinine in comparison to the control mice. The results showed that consumption of crude plant extract at a dose 100 mg and above per kg body weight continuously for long time may cause toxic effects to its consumer.