Kapoor R and Dhole TN
Objective: Human bocavirus is responsible for respiratory as well as in gastroenteritis illness in several countries including India. This study was aimed to characterize the Human bocavirus in North Indian children suffering with acute gastroenteritis.
Methods: A total of 234 diarrheal stool specimens from the children under the age of 15 years were collected and screened for the presence of Human bocavirus by polymerase chain reaction targeting NS1 and VP1/2 gene followed by sequencing and phylogenetic analysis. Student’s t test was performed for statistical analysis of quantitative clinical data.
Results: Total 7 (3%) samples were positive for Human bocavirus including bocavirus1 (n=4, 1.7%) and bocavirus2 (n=3, 1.3%). Median age of bocavirus positive children was 8 months (mean ± SD; 24.14 ± 27.58 months). Age, duration of diarrhea and episodes of diarrhea were the significant clinical factors (p values 0.0486, 0.0015 and 0.0282 respectively) for bocavirus infection. Interestingly, male were dominated than females (6:1). Phylogenetic analysis showed that Indian bocavirus sequence has similarity with China strains.
Conclusion: Detection of two bocavirus species in gastroenteritis from North India supports global presence of bocavirus. The outcome of the study facilitates more detailed studies of bocavirus infection, its prevalence and disease association in Indian population.
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