மருந்தியல் மற்றும் இயற்கை தயாரிப்புகளின் இதழ்

The Search For, and Chemistry and Mechanism of, Neurotrophic Natural Products

Abstract

Kevin Fredo

Neurotrophic factors, currently termed neurotrophins, that belong to a category of polypeptidyl agents, are shown to probably be helpful for the treatment of neurodegenerative maladys like Alzheimer’s disease, as a result of endogenous neurotrophic factors (NGF, BDNF, NT3, NT4) are recognized to play vital roles within the promotion of ontogeny, differentiation, and neuroprotection throughout the event of the central system. However, high-molecular weight proteins square measure unable to cross the blood–brain barrier and square measure simply rotten by proteolytic enzyme underneath physiological conditions. To handle this issue, tiny molecules which will mimic the functions of neurotrophic factors would be promising alternatives for the treatment of neurodegenerative malady. We’ve got continuing to go looking for natural product having typical neurotrophic properties, which might cause ontogeny, enhance neurite outgrowth, and shield neuronic death exploitation 3 cellular systems (PC12, rat plant tissue neurons, and MEB5 cells). during this review, we tend to summarize the neurotrophic activities and synthesis of dimeric isocuparane-type sesquiterpenes from the nonvascular plant, class diclados, the mechanism of neurotrophic neolignans, magnolol, honokiol and their sesquiterpene derivatives, and introduce distinctive neurotrophin-mimic natural product, as well as seco-prezizaane-type sesquiterpenes from the magnoliid dicot genus species, vibsane-type diterpenes from genus Viburnum awabuki, and miscellaneous natural product with neurotrophic effects discovered by North American nation.