Lixi Tian
The exercise interventions were delivered in the community, enhancing generalizability but possibly introducing variability in execution. For instance, it is still unknown if increased cardiorespiratory fitness correlates with improved memory, or if memory loss (or more advanced forms of dementia) influences measured cardiorespiratory fitness as measured by peak VO2 levels. Although these relationships remained significant even after controlling for baseline MMSE or baseline CDR (as an index of baseline disease severity), reverse causation cannot be ruled out as an explanation for these secondary findings. Last but not least, it is essential to note that we did not make any corrections for any of the tests, increasing the likelihood of false positives.
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