Karri VVSR, Raman SK, Kuppusamy G, Sanapalli BKR, Wadhwani A, et al.
Terbinafine HCl (TBH) is a broad spectrum antifungal agent used against dimorphic fungi, yeast, molds, dematiaceous fungi and dermatophytes. However, the poor solubility of this potential molecule renders it efficacy limited. So, the combinations of oral and topical doses are prescribed. Hence, the aim of the current study was to increase the solubility of TBH by incorporating into Nanoemulsion gel (NEG) and to investigate it’s in vitro antifungal activity using Candida albicans as a fungal inoculum. The TBH nanoemulsion was prepared using high speed homogenization technique and evaluated for its micromeritcs. The particles results revealed that acceptable globule size of 11.47 nm with a PDI of 0.556. The obtained nanoemulsion was converted in to NEG and evaluated for in vitro permeation and in vitro antifungal activity. The permeation studies reveled that NEG (76.23 ± 2.81%) has higher permeation, when compared to marketed cream (MC 29.37 ± 1.82%). In vitro Antifungal studies showed that the prepared NEG (0.66 ± 0.17 mm) has high zone of inhibition (p<0.01) almost to that of pure drug solution (0.91 ± 0.07 mm) compared to MC (0.13 ± 0.05 mm). Hence, the formulated NEG of TBH may best suitable for delivery of poorly soluble drugs like TBH, which are intended for topical antifungal application.
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