உருவவியல் மற்றும் உடற்கூறியல் இதழ்

Post-traumatic epileptogenesis (PTE) refers to the process by which a traumatic brain injury (TBI) leads to the development of epilepsy. Identifying reliable biomarkers for PTE is crucial for early detection, prognosis, and personalized treatment strategies. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have emerged as promising candidates for biomarker discovery in PTE. This article provides an overview of the role of miRNAs in PTE and discusses their potential as biomarkers for predicting epileptogenesis following TBI. Key findings from preclinical and clinical studies investigating miRNA expression changes in TBI-induced epileptogenesis are summarized, highlighting their diagnostic and prognostic utility. Furthermore, challenges and future directions in miRNA biomarker research for PTE are discussed, emphasizing the importance of translational efforts to harness the full potential of miRNAs in clinical practice.

Mesenchymal Stromal Cells (MSCs) hold immense potential in regenerative medicine, particularly in cartilage repair and regeneration. However, the impact of chronological age on the chondrogenic capacity of MSCs remains a subject of intense investigation and debate. This article provides a comprehensive analysis of the relationship between chronological age and MSCs' ability to undergo chondrogenesis. Through an examination of relevant studies, key factors influencing age-related changes in MSCs, such as proliferation capacity, differentiation potential, gene expression profiles, and extracellular matrix composition, are discussed. Additionally, strategies to overcome age-related limitations and enhance chondrogenic potential are explored. Understanding the age-related dynamics of MSCs in chondrogenesis is crucial for optimizing regenerative therapies and addressing challenges associated with cartilage repair in aging populations.

Fluoroscopy-guided pediatric cardiac interventional procedures require high-quality X-ray imaging systems to ensure accurate visualization of anatomical structures and devices. This article explores the importance of physical image quality metrics in assessing the performance of X-ray systems utilized in pediatric cardiac interventions. Various quantitative parameters, including spatial resolution, noise characteristics, contrast-to-noise ratio, and radiation dose metrics, are discussed in the context of optimizing image quality while minimizing radiation exposure to pediatric patients. Understanding and implementing these metrics are essential for enhancing procedural outcomes and ensuring patient safety in pediatric cardiac interventions.

Antibacterial substances incorporated into dental resin composites have gained significant attention due to their potential in preventing secondary caries and improving oral health outcomes. This article provides a comprehensive analysis of various antibacterial agents utilized in modifying dental resin composites, highlighting their mechanisms of action, effectiveness, limitations, and future prospects. Key factors such as antimicrobial spectrum, biocompatibility, stability, and long-term efficacy are discussed, along with recent advancements and emerging trends in this field.