..

ஜர்னல் ஆஃப் மெட்டபாலிக் சிண்ட்ரோம்

ஐ.எஸ்.எஸ்.என்: 2167-0943

திறந்த அணுகல்
கையெழுத்துப் பிரதியை சமர்ப்பிக்கவும் arrow_forward arrow_forward ..

Lipotoxicity: Understanding the Dangerous Effects of Excessive Lipids on Cellular Health

Abstract

John Hebrew*

Lipotoxicity is a condition characterized by the harmful effects of excessive lipids on cellular health. It plays a significant role in the development of metabolic disorders such as obesity, type 2 diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), and cardiovascular complications. The accumulation of lipids, particularly Free Fatty Acids (FFAs), disrupts cellular function through mechanisms such as impaired insulin signalling, Endoplasmic Reticulum (ER) stress, oxidative stress, and mitochondrial dysfunction. This article provides an in-depth exploration of lipotoxicity, including its mechanisms, consequences, interventions, and future directions. Understanding lipotoxicity is crucial for developing effective strategies to prevent and manage its detrimental effects on human health.

இந்தக் கட்டுரையைப் பகிரவும்

ஜர்னல் ஹைலைட்ஸ்

குறியிடப்பட்டது

arrow_upward arrow_upward