ஜர்னல் ஆஃப் மெட்டபாலிக் சிண்ட்ரோம்

Metabolic Syndrome Biomarkers in Type II Diabetic Ethiopian Patients

Abstract

Fitsum Girma Tadesse, Yesehak Worku, Yeweyenhareg Feleke and Tarek H. El-Metwally

Background: Insulin resistance, which precedes by many years the onset of and accompanies type II diabetes (T2D), is strongly associated with a clustering of cardiovascular risk factors, termed metabolic syndrome (MetS).

Objectives: The aim of this study was to investigate the extent of MetS risk in T2D Ethiopian patients.

Methods: A total of 72 T2D patients and 20 normal healthy controls without MetS were studied. Based on the world health organization criteria, 59.72% (43/72) of the patients had MetS.

Results: Type 2 diabetic patients with MetS (0.953 ± 0.007) were significantly (P<0.01) obese than those without (0.913 ± 0.012). Plasma total triglyceride (TG) (206.9 ± 16.91) and blood pressure (138.8 ± 3.247) were strongly significantly high (P<0.001) in patients with MetS as compared to those without MetS (104.4 ± 6.766 and 122.8 ± 2.725, respectively). On the other hand, plasma high density lipoprotein-cholesterol (40.91 ± 3.070) and total peroxide (0.055 ± 0.001) were found at a significantly (P<0.05) lower amounts in patients with MetS as compared to those without (50.90 ± 2.601 and 0.052 ± 0.001, respectively). In patients with MetS, the IR index showed a significant association (P<0.05) with the dyslipidemia markers: TG (r=0.254), low density lipoprotein-cholesterol (r=0.262), and total cholesterol (r=0.320). Waist-hip circumference ratio showed a positive significant correlation with blood pressure (r=0.330, P<0.05) and C-reactive protein was strongly associated with serum insulin concentration (r=0.382, P<0.01).

Conclusion: Ethiopian T2D patients with MetS are at a greater risk of hypertensive, dyslipidemia and oxidative stress states, and developing cardiovascular disorders. Interventions should be planned to help those patients avoid/delay onset of cardiovascular complications anticipated upon the accumulation of predisposing factors that are components of MetS.