உணவு மற்றும் தொழில்துறை நுண்ணுயிரியல் இதழ்

Probiotic Potential of Lactobacillus Strains on the Adipogenesis of 3T3-L1 Cells

Abstract

Kang CH, So JS, Han SH, Kim YG, Jeong Y, Kim JS and Paek NS

Obesity is the most common health problem in developed countries and is considered a significant risk factor for many major human diseases. This study aimed to evaluate the inhibitory effect of lactic acid bacteria isolated from the human vagina on adipocyte differentiation in 3T3-L1 preadipocytes. We screened 26 strains of lactic acid bacteria to test their effects against obesity. Among the tested strains, Lactobacillus gasseri MG2855 exhibited a lipase inhibitory activity of 11.84% and inhibited relative lipid content of 3T3-L1 cells (96.21%) at a concentration of 1,000 μg/mL. The survival rate of L. gasseri MG2855 in 0.3% bile salt was 88.47%, and the survival rate after incubation for 3 h in pH 3.0 was 78.64%. L. gasseri MG2855 showed higher sensitivity to erythromycin, chloramphenicol, tetracyclin, and cephalothin in 16 antibiotic sensitivity tests. These results demonstrate that L. gasseri MG2855 can be employed as a potential probiotic with anti-obesity effects.